Research Article
The Impact of IL-16 3′UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals
Table 7
The relationship between IL-16-rs859, CYP24A1-rs4809957,and FBN1-rs1042078 and lung small cell carcinoma risk.
| | Gene | SNP | Model | Genotype | Control | Case | Crude Analysis | Adjusted Analysis | | (N = 384) | (N = 74) | OR (95% CI) | P-value | OR (95% CI) | P-value |
| IL-16
(N = 458) | rs859
(call rate 99.78%) | Codominant | A/A | 92 (24.0%) | 22 (30.1%) | 1.00 | 0.480 | 1.00 | 0.110 | | G/A | 190 (49.5%) | 35 (48.0%) | 0.77 (0.43-1.39) | 0.58 (0.30-1.11) | | G/G | 102 (26.6%) | 16 (21.9%) | 0.66 (0.32-1.32) | 0.46 (0.21-0.99) | | Dominant | A/A | 92 (24.0%) | 22 (30.1%) | 1.00 | 0.270 | 1.00 | 0.047 | | G/A-G/G | 292 (76.0%) | 51 (69.9%) | 0.73 (0.42-1.27) | 0.53 (0.29-0.98) | | Recessive | A/A-G/A | 282 (73.4%) | 57 (78.1%) | 1.00 | 0.400 | 1.00 | 0.200 | | G/G | 102 (26.6%) | 16 (21.9%) | 0.78 (0.43-1.41) | 0.66 (0.35-1.26) | | Log-additive | --- | --- | --- | 0.81 (0.57-1.15) | 0.230 | 0.67 (0.46-0.99) | 0.044 |
| CYP24A1
(N = 458) | rs4809957
(call rate 100%) | Codominant | G/G | 143 (37.2%) | 28 (37.8%) | 1.00 | 0.770 | 1.00 | 0.710 | | G/A | 185 (48.2%) | 33 (44.6%) | 0.91 (0.53-1.58) | 0.88 (0.48-1.59) | | A/A | 56 (14.6%) | 13 (17.6%) | 1.19 (0.57-2.45) | 1.21 (0.55-2.64) | | Dominant | G/G | 143 (37.2%) | 28 (37.8%) | 1.00 | 0.920 | 1.00 | 0.860 | | G/A-A/A | 241 (62.8%) | 46 (62.2%) | 0.97 (0.58-1.63) | 0.95 (0.55-1.66) | | Recessive | G/G-G/A | 328 (85.4%) | 61 (82.4%) | 1.00 | 0.520 | 1.00 | 0.480 | | A/A | 56 (14.6%) | 13 (17.6%) | 1.25 (0.64-2.42) | 1.30 (0.64-2.65) | | Log-additive | --- | --- | --- | 1.02 (0.69-1.64) | 0.690 | 1.05 (0.71-1.55) | 0.800 |
| FBN1
(N = 458) | rs1042078
(call rate 100%) | Codominant | A/A | 117 (30.5%) | 20 (27.0%) | 1.00 | 0.150 | 1.00 | 0.160 | | A/G | 185 (48.2%) | 44 (59.5%) | 1.39 (0.78-2.48) | 1.30 (0.70-2.41) | | G/G | 82 (21.4%) | 10 (13.5%) | 0.71 (0.32-1.60) | 0.63 (0.26-1.49) | | Dominant | A/A | 117 (30.5%) | 20 (27.0%) | 1.00 | 0.550 | 1.00 | 0.780 | | A/G-G/G | 267 (69.5%) | 54 (73.0%) | 1.18 (0.68-2.07) | 1.09 (0.60-1.98) | | Recessive | A/A-A/G | 302 (78.7%) | 64 (86.5%) | 1.00 | 0.110 | 1.00 | 0.084 | | G/G | 82 (21.4%) | 10 (13.5%) | 0.58 (0.28-1.17) | 0.53 (0.25-1.13) | | Log-additive | --- | --- | --- | 0.91 (0.64-1.31) | 0.620 | 0.85 (0.58-1.26) | 0.430 |
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SNP: Single Nucleotide Polymorphism; OR: Odds Ratio; 95% CI: 95% Confidence Interval. P-value: P-values calculated by unconditional logistic regression analysis. P-value: P-values calculated by unconditional logistic regression analysis with adjustment for age, gender, smoking status, and alcohol drinking status. Bold italics indicates the statistical significance ( P < 0.05). |
