Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis

Figure 6

HFD could increase the levels of CA and DCA, leading to upregulating the expression of small intestinal TPH1 and then increase the serotonin concentration of small intestine, which fastens the gastrointestinal motility. Furthermore, after receiving FMT, the decreased levels of CA and DCA could downregulate the expression of TPH1 and reduce the serotonin concentration in the gut and then relieve the gastrointestinal dysmotility. In addition, DCA can also promote gastrointestinal motility.