Prognostic Significance of Expression in Penile Squamous Cell Carcinoma: A Meta-Analysis with Trial Sequential Analysis

Table 1

Main characteristics of included studies.

First author & Study year	Nationality	Age (yrs)	positive (n)	negative (n)	Detection method	Cut-off value	Follow-up time (yrs)	HR	95% CI
Bethune 2012	Canada	63.0 mean	23	20	IHC	>0	3.9 mean		0.26–1.06
Gunia 2012	Germany	67.2 mean	54	38	IHC	>0	2.7 median		0.23–0.84
Ferrándiz 2013	Spain	69.0 median	31	47	IHC	H-score: 50	2.5 median		0.02–0.98
Bezerra 2015	United States	65.0 median	23	30	IHC	NM	NM		0.13–2.19
Zargar 2016	United States	60.0 median	23	34	IHC	Median	1.8 median		0.16–1.20

n, number; IHC, immunohistochemistry; yrs, years; NM, not mentioned; H-score, histological score; HR, hazard ratio; CI, confidence interval;
, HR outcome directly reported by studies; *, HR outcome extracted from survival curve.