Systematic Analysis of RNA Regulatory Network in Rat Brain after Ischemic Stroke

Figure 3

lncRNAs mediate SMD in ischemic stroke. (a) Expression of Staufen1 and Staufen2 in the ischemia and nonischemia rat brain after ischemic stroke. (b) Distribution of SINEs (B1, B2, and B4 element) in mRNA 3′UTR and lncRNAs in the ischemia rat brains. (c) Distribution of SINEs in mRNA 3′UTR and lncRNAs in the nonischemia rat brains. (d) SMD regulatory network of differentially expressed genes. (e) SMD network filtered by duplex energy. (f) Examples of two Alu-based lncRNA:mRNA duplex. Red triangle represents lncRNAs and blue square represents coding genes.

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