Effect of Astragalus Polysaccharides on Cardiac Dysfunction in db/db Mice with Respect to Oxidant Stress

Figure 2

Effects of APS on ultra-structural pathological changes of myocardium in db/db mice. Left ventricular samples from C57BJ/6J mice and db/db mice with or without APS treatment (n=6 per group) were prepared and evaluated by transmission electron microscopy (TEM) analysis. (a)~(c) Representative transmission electron microscopy photographs of cardiomyocytes. Disrupted tubes, sarcomeres, and mitochondrial cristae were noted in cardiac myocytes from db/db mice (b), whereas TEM Features in hearts from APS-treated db/db mice (c) showed nearly normal-appearing mitochondrial cristae, tubes, and sarcomeres that resembled those from normal control (a) (original magnification:×22500).

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