Tumor-Associated CD204-Positive Macrophage Is a Prognostic Marker in Clinical Stage I Lung Adenocarcinoma

Table 1

Correlation between CD204+ macrophage density and clinicopathological features.

Clinical or pathologic feature	Total	CD204 [ (%)]		p value
		Low	High
All cases	182	119 (65.4)	63 (34.6)
Gender				0.981
Men	84	55 (65.5)	29 (34.5)
Women	98	64 (65.3)	34 (34.7)
Age (years)				0.745
<70	101	65 (64.4)	36 (35.6)
≥70	81	54 (66.7)	27 (33.3)
Side				0.769
Left	72	48 (66.7)	24 (33.3)
Right	110	71 (64.5)	39 (35.5)
History of smoking				0.494
Yes	89	56 (62.9)	33 (37.1)
No	93	63 (67.7)	30 (32.3)
Histologic subtype				0.027
Lepidic	104	75 (72.1)	29 (27.9)
Acinar	39	23 (59.0)	16 (41.0)
Papillary	14	5 (35.7)	9 (64.3)
Solid	21	12 (57.1)	9 (42.9)
Mucinous	4	4 (100)	0 (0)
Tumor stage				0.008
cT1a	116	84 (71.8)	32 (28.2)
cT1b	66	35 (53.0)	31 (47.0)
Nodal involvement				<0.001
Absent	166	116 (69.9)	50 (30.1)
Present	16	3 (18.8)	13 (81.2)
Lymphovascular invasion				<0.001
Absent	141	104 (73.8)	37 (26.2)
Present	41	15 (36.6)	26 (63.4)
Recurrence				<0.001
Absent	161	117 (72.7)	44 (27.3)
Present	21	2 (9.5)	19 (90.5)