Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes

Table 4

Hematological values of male rats after 4 weeks of AgNP, AuNP, and AgNP/AuNP mix administration (n-5).

Dose (μg/kg)	G1	G2	G3	G4	G5	G6	G7
	Control	Silver 10	Silver 100	Gold 10	Gold 100	Mix 10	Mix 100
WBC^1 (K/μL)	6.96±0.52	6.30±0.46	7.06±0.75	6.27±1.25	8.01±1.02	8.51±0.37	5.15±0.56
NE^2 (K/μL)	1.14±0.14	1.35±0.23	1.56±0.35	0.88±0.18	1.01±0.17	1.13±0.27	0.86±0.17
LY^3 (K/μL)	5.61±0.52	4.71±0.27	5.28±0.62	5.14±1.04	6.69±0.91	7.13±0.50	4.11±0.43
MO^4 (K/μL)	0.09±0.01	0.11±0.03	0.11±0.02	0.10±0.02	0.18±0.03	0.13±0.03	0.07±0.01
EO^5 (K/μL)	0.06±0.01	0.05±0.01	0.08±0.01	0.08±0.01	0.10±0.02	0.09±0.01	0.08±0.01
BA^6 (K/μL)	0.01±0.002	0.01±0.002	0.004±0.002	0.004±0.002	0.002±0.002	0.01±0.002	0.01±0.002
NE^7 (%)	16.86±2.69	21.06±2.79	21.84±3.33	14.30±1.78	12.82±1.46	13.48±3.30	16.40±2.36
LY^8 (%)	80.08±2.53	75.30±3.00	74.88±3.45	82.02±1.92	83.22±1.61	83.56±3.30	80.08±2.12
MO^9 (%)	1.30±0.16	1.72±0.25	1.54±0.28	1.46±0.19	2.30±0.35	1.52±0.45	1.42±0.23
EO^10 (%)	0.82±0.10	0.86±0.14	1.24±0.20	1.40±0.19	1.34±0.19	1.10±0.12	1.50±0.17
BA^11 (%)	0.06±0.02	0.08±0.04	0.06±0.02	0.60±0.02	0.06±0.02	0.06±0.02	0.10±0.03
RBC^12 (M/μL)	7.85±0.34	7.89±0.18	8.28±0.11	8.16±0.25	8.28±0.29	8.11±0.14	8.11±0.19
Hb^13 (g/dL)	15.12±0.51	15.36±0.32	15.74±0.21	15.10±0.34	15.48±0.36	15.74±0.27	15.56±0.26
HCT^14 (%)	46.02±1.32	47.12±1.17	47.48±0.59	45.72±1.15	46.58±1.10	47.16±0.73	47.30±0.69
MCV^15 (fL)	58.82±1.02	59.68±0.57	57.44±1.22	56.12±0.91	56.36±0.69	58.20±0.29	58.40±0.70
MCH^16 (pg)	19.30±0.30	19.46±0.17	19.04±0.44	18.52±0.39	18.72±0.23	19.42±0.07	19.18±0.19
MCHC^17 (g/dL)	32.84±0.31	32.62±0.24	33.12±0.12	32.98±0.17	33.22±0.13	33.36±0.27	32.90±0.16
RDW^18 (% )	11.60±0.60	11.78±0.32	11.42±0.24	11.50±0.22	11.80±0.34	11.60±0.45	11.60±0.32
PLT^19 (K/μL)	1176.00±39.04	1123.00±49.29	1053.60±56.59	1167.40±74.05	1210.80±71.8	1151.60±49.26	1094.60±23.74
MPV^20 (fL)	10.64±0.56	11.64±0.19	11.24±0.27	9.44±1.07	10.02±0.38	9.16±0.44	10.58±0.26

1, white blood cell; 2, neutrophils; 3, lymphocyte; 4, monocyte; 5, eosinophil; 6, basophil; 7, percent of neutrophils; 8, percent of lymphocyte; 9, percent of monocyte; 10, percent of eosinophil; 11, percent of basophil; 12, red blood cell; 13, hemoglobin; 14, hematocrit; 15, mean corpuscular volume; 16, mean corpuscular hemoglobin; 17, mean corpuscular hemoglobin concentration; 18, red cell distribution width; 19, platelet; 20, mean platelet volume; a: p<0.05, compared with G5 and G6 group; b: p<0.05, compared with G4 and G7 group; c: p<0.05, compared with G2 group; d: p<0.05, compared with G3 and G2 group.