Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes

Table 5

Hematological values of male rats in after 4 weeks of recovery (n=3).

Dose (µg/kg)	G1	G2	G3	G4	G5	G6	G7
	Control	Silver 10	Silver 100	Gold 10	Gold 100	Mix 10	Mix 100
WBC^1 (K/μL)	5.90±1.17	5.11±0.42	7.38±0.29	5.48±1.37	7.07±0.72	6.55±0.94	7.95±1.05
NE^2 (K/μL)	0.93±0.15	0.95±0.05	1.44±0.09	1.21±0.24	0.82±0.09	0.99±0.20	0.79±0.13
LY^3 (K/μL)	4.84±1.17	3.98±0.42	5.77±0.50	4.13±1.14	5.96±0.58	5.27±0.64	6.89±1.07
MO^4 (K/μL)	0.05±0.01	0.08±0.02	0.08±0.03	0.03±0.01	0.17±0.06	0.17±0.08	0.14±0.04
EO^5 (K/μL)	0.07±0.01	0.10±0.03	0.08±0.01	0.09±0.01	0.11±0.02	0.10±0.02	0.12±0.01
BA^6 (K/μL)	0.00±0.00	0.00±0.00	0.00±0.00	0.003±0.003	0.00±0.00	0.003±0.003	0.003±0.003
NE^7 (%)	16.87±3.96	18.90±2.35	19.70±2.10	22.67±2.38	11.63±0.87	14.83±0.90	10.20±2.31
LY^8 (%)	80.97±3.70	77.63±1.64	77.90±2.50	74.73±2.55	84.33±1.05	81.00±1.85	86.20±2.95
MO^9 (%)	0.90±0.15	1.53±0.35	1.20±0.47	0.67±0.07	2.23±0.72	2.33±0.83	1.73±0.52
EO^10 (%)	1.17±0.07	1.80±0.40	1.10±0.15	1.80±0.26	1.63±0.27	1.53±0.12	1.60±0.17
BA^11 (%)	0.00±0.00	0.03±0.03	0.03±0.03	0.03±0.03	0.00±0.00	0.07±0.03	0.03±0.03
RBC^12 (M/μL)	8.29±0.10	8.16±0.25	8.05±0.29	8.40±0.23	8.25±0.26	8.11±0.28	8.54±0.06
Hb^13 (g/dL)	15.23±0.33	15.30±0.53	15.30±0.15	14.93±0.20	15.70±0.46	15.40±0.25	16.13±0.24
HCT^14 (%)	44.50±0.92	45.10±1.25	45.70±0.36	45.23±0.67	46.57±1.47	47.27±0.88	48.30±1.08
MCV^15 (fL)	53.67±0.62	55.20±0.70	56.90±2.44	53.97±1.94	56.43±0.68	58.50±3.13	56.57±1.17
MCH^16 (pg)	18.37±0.24	18.73±0.26	19.07±0.71	17.77±0.35	18.97±0.12	19.07±0.98	18.90±0.32
MCHC^17 (g/dL)	34.23±0.09	33.93±0.23	33.50±0.59	33.03±0.52	33.70±0.21	32.63±0.15	33.40±0.45
RDW^18 (% )	13.07±0.77	13.27±0.35	12.67±0.23	13.17±0.52	12.67±0.20	12.83±0.07	12.50±0.36
PLT^19 (K/μL)	1010.67±54.05	1052.33±36.39	1096.00±65.82	1006.00±36.51	768.67±330.74	1068.67±72.09	991.00±130.50
MPV^20 (fL)	10.13±0.15	9.10±0.35	7.67±1.52	10.23±0.38	10.37±0.12	8.93±0.43	6.53±0.66

1, white blood cell; 2, neutrophils; 3, lymphocyte; 4, monocyte; 5, eosinophil; 6, basophil; 7, percent of neutrophils; 8, percent of lymphocyte; 9, percent of monocyte; 10, percent of eosinophil; 11, percent of basophil; 12, red blood cell; 13, hemoglobin; 14, hematocrit; 15, mean corpuscular volume; 16, mean corpuscular hemoglobin; 17, mean corpuscular hemoglobin concentration; 18, red cell distribution width; 19, platelet; 20, mean platelet volume. a: p<0.05, compared with G2, G3, and G4 group; b: p<0.01, compared with G1, G2, G4, G5, and G6 group.