Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes

Table 6

Serum biochemical values of male rats after 4 weeks of AgNP, AuNP, and AgNP/AuNP mix administration (n=5).

Dose (µg/kg)	G1	G2	G3	G4	G5	G6	G7
	Control	Silver 10	Silver 100	Gold 10	Gold 100	Mix 10	Mix 100
ALB^1 (g/dL)	2.16±0.04	2.22±0.05	2.16±0.02	2.16±0.05	2.08±0.05	2.08±0.04	2.10±0.03
ALP^2 (IU/L)	460.00±45.56	542.40±44.53	619.00±93.65	553.60±54.12	455.40±38.02	551.20±32.65	516.40±20.01
CA^3 (mg/dL)	9.34±0.07	9.14±0.08	9.50±0.25	9.14±0.11	9.38±0.17	9.38±0.13	9.68±0.35
CHO^4 (mg/dL)	62.20±8.13	58.4010.18	67.20±8.79	67.60±3/59	62.60±7.57	51.00±2.81	54.00±3.44
CRE^5 (mg/dL)	0.57±0.01	0.59±0.06	0.56±0.03	0.53±0.03	0.59±0.02	0.62±0.04	0.57±0.02
γ-GT^6 (IU/L)	0.40±0.24	0.20±0.20	0.80±0.20	0.80±0.20	0.60±0.24	0.80±0.20	0.40±0.24
GLU^7 (mg/dL)	123.80±7.29	149.60±9.83	164.40±10.21	138.00±8.32	152.80±10.27	164.00±15.11	139.40±3.85
AST^8 (IU/L)	133.80±11.32	132.60±11.73	111.80±15.69	120.60±8.37	105.60±13.98	121.60±25.58	124.80±7.28
ALT^9 (IU/L)	26.40±1.50	29.60±2.09	27.00±2.21	28.00±1.92	27.20±1;56	42.20±12.21	38.00±9.83
IP^10 (mg/dL)	8.76±0.27	8.22±0.17	8.68±0.19	8.20±0.24	8.08±0.11	8.56±0.24	8.48±0.51
LDH^11 (IU/L)	1587.60±176.42	1203.00±136.51	955.00±362.86	1123.40±201.42	641.00±290.21	728.40±288.19	1141.20±129.71
MG^12 (mg/dL)	2.10±0.06	2.10±0.13	2.04±0.04	1.90±0.05	1.94±0.07	2.14±0.06	2.14±0.07
TP^13 (g/dL)	5.38±0.08	5.54±0.09	5.50±0.14	5.54±0.09	5.46±0.09	5.44±0.11	5.36±0.14
UA^14 (mg/dL)	1.20±0.07	1.44±0.20	1.24±0.08	1.20±0.06	1.30±0.05	1.44±0.09	1.16±0.04
BUN^15 (mg/dL)	13.34±0.51	15.52±0.39	13.84±0.83	13.76±0.71	14.78±0.61	14.12±0.61	13.02±0.77
TBIL^16(mg/dL)	0.05±0.02	0.05±0.01	0.07±0.01	0.05±0.01	0.05±0.01	0.06±0.003	0.05±0.01
TG^17 (mg/dL)	38.00±7.89	24.60±6.36	43.40±16.23	29.20±6.87	28.60±4.79	30.20±5.07	20.80±3.01
CK^18 (IU/L)	804.20±80.00	1209.80±336.07	726.20±144.96	666.20±95.67	1019.60±379.80	704.20±125.70	748.80±27.43
Na^19 (mmol/L)	146.40±0.51	144.80±0.49	145.40±0.40	145.00±0.55	144.40±0.24	144.40±0.51	146.40±0.24
K^20 (mmol/L)	4.40±0.22	4.70±0.11	4.68±0.10	4.80±0.06	4.60±0.08	4.72±0.11	4.60±0.12
Cl^21 (mmol/L)	103.40±0.24	103.20±0.37	104.80±0.49	104.40±0.81	103.40±0.24	103.80±0.58	104.60±0.51

1, albumin; 2, alkaline phosphatase; 3, calcium; 4, cholesterol; 5, creatinine; 6, gamma glutamyl transpeptidase; 7, glucose; 8, aspartate amino transaminase; 9, alanine amino transaminase; 10, inorganic phosphorus; 11, lactate Dehydrogenase; 12, magnesium; 13, total protein; 14, uric acid; 15, blood urea nitrogen; 16, total bilirubin; 17, triglyceride; 18, creatine Kinase; 19, sodium; 20, potassium; 21, chloride. a: p<0.01, compared with G1 and G7 group.