Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes

Table 7

Serum biochemical values of male rats after 4 weeks of recovery (n=3).

Dose (μg/kg)	G1	G2	G3	G4	G5	G6	G7
	Control	Silver 10	Silver 100	Gold 10	Gold 100	Mix 10	Mix 100
ALB^1 (g/dL)	2.17±0.03	2.13±0.03	2.10±0.00	2.10±0.05	2.13±0.03	2.27±0.07	2.10±0.00
ALP^2 (IU/L)	300.00±29.46	359.33±49.50	316.67±26.86	259.00±26.08	296.00±36.10	300.67±29.34	298.67±11.89
CA^3 (mg/dL)	9.30±0.10	9.37±0.19	9.67±0.15	9.57±0.12	9.37±0.20	9.57±0.09	9.63±0.09
CHO^4 (mg/dL)	75.67±11.26	61.00±11.68	64.67±9.00	60.00±4.04	73.67±17.84	90.33±6.77	68.67±5.82
CRE^5 (mg/dL)	0.55±0.02	0.51±0.01	0.52±0.05	0.48±0.04	0.51±0.04	0.53±0.02	0.48±0.04
γ-GT^6 (IU/L)	0.33±0.33	0.33±0.33	0.00±0.00	1.00±0.00	0.33±0.33	0.00±0.00	0.33±0.33
GLU^7 (mg/dL)	131.33±4.37	132.67±6.69	150.67±6.17	144.33±8.19	137.33±6,44	168.67±12.33	176.33±2.73
AST^8 (IU/L)	185.00±24.99	164.33±10.68	195.67±45.19	130.00±7.09	160.00±9.81	180.00±21.79	100.33±15.25
ALT^9 (IU/L)	35.67±2.33	38.67±1.20	56.00±24.58	30.67±1.33	34.67±1,20	37.67±2.19	38.33±7.13
IP^10 (mg/dL)	6.97±0.12	7.30±0.32	7.60±0.29	7.30±	7.80±0.32	7.23±0.22	6.50±0.31
LDH^11 (IU/L)	2007.00±466.88	1373.33±196.70	1467.67±41.00	952.00±166.73	1663.00±96.63	1650.67±458.90	202.67±41.58
MG^12 (mg/dL)	1.00±0.00	2.00±0.00	3.00±0.00	4.00±0.00	5.00±0.00	6.00±0.00	7.00±0.00
TP^13 (g/dL)	5.77±0.09	5.50±0.12	5.50±0.06	5.43±0.13	5.73±0.07	5.83±0.18	5.70±0.06
UA^14 (mg/dL)	1.23±0.13	1.37±0.07	1.13±0.13	1.33±0.09	1.20±0.10	1.30±0.10	1.03±0.12
BUN^15 (mg/dL)	16.10±0.10	15.50±0.06	17.50±1.21	14.37±1.21	17.23±0.15	18.37±1.46	14.77±0.24
TBIL^16(mg/dL)	0.05±0.01	0.05±0.01	0.08±0.01	0.08±0.02	0.04±0.02	0.08±0.01	0.08±0.01
TG^17 (mg/dL)	43.00±13.45	34.67±15.67	36.33±10.91	31.33±5.81	46.00±10.15	44.00±6.93	48.67±8.21
CK^18 (IU/L)	1237.67±346.14	1299.67±114.17	1007.00±243.60	705.00±73.66	1293.33±154.34	1093.33±109.25	829.33±316.17
Na^19 (mmol/L)	143.67±0.33	145.00±0.58	144.33±0.33	145.33±0.67	146.00±0.58	146.67±0.88	145.67±0.67
K^20 (mmol/L)	4.77±0.15	4.80±0.06	4.67±0.12	4.47±0.12	4.93±0.13	4.70±0.10	4.33±0.12
Cl^21 (mmol/L)	103.33±0.33	104.33±0.33	104.33±0.33	106.00±0.58	105.33±1.20	104.67±0.67	106.33±0.88

1, albumin; 2, alkaline phosphatase; 3, calcium; 4, cholesterol; 5, creatinine; 6, gamma glutamyl transpeptidase; 7, glucose; 8, aspartate amino transaminase; 9, alanine amino transaminase; 10, inorganic phosphorus; 11, lactate dehydrogenase; 12, magnesium; 13, total protein; 14, uric acid; 15, blood urea nitrogen; 16, total bilirubin; 17, triglyceride; 18, creatine Kinase; 19, sodium; 20, potassium; 21, chloride:; a: p<0.01, compared with G6 and G7 group.