Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERK/STAT3/NF-κB Pathway

Figure 1

Antiviral activity evaluation of SAM against CVA16 infection in mice. Different groups of 5-day-old BALB/c mice were inoculated i.p. with 2×10⁶ TCID50 of CA16 or with PBS. The inoculated mice were monitored daily for (a) survival and (b) clinical scores. Clinical scores were graded as follows: 0, healthy; 1, reduced mobility; 2, limb weakness; 3, paralysis; 4, death. (c) The virus load in the brain, blood, heart, skeletal muscle, and lungs was measured by real-time PCR. Results are expressed as viral RNA copies/mg tissue or μl blood. (d) Effects of SAM on virus load in brain. Results are expressed as viral RNA copies/mg tissue. ^##P<0.01 versus control group; ^∗∗P<0.01 versus model group.

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