Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERK/STAT3/NF-κB Pathway

Figure 3

Effect of SAM on apoptosis in brain subjected to CA16 infection. Different groups of 1-day-old BALB/c mice were inoculated i.p. with 2×10⁶ TCID50 of CA16 or with PBS, then SAM were i.p. given for 15 days. (a) Effects of SAM on virus load in brain. LDH (b), CK-MB (c), and caspase 3 levels (d) in serum were detected by the corresponding kits according to the instructions. (e) Cleaved-caspase 3, Bax, and Bcl-2 expression in brain were measured by Western blotting. ^##P<0.01 versus control group; ^∗P<0.05; ^∗∗P<0.01 versus model group.

(a)

(b)

(c)

(d)

(e)