Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERK/STAT3/NF-κB Pathway

Figure 4

Effect of SAM on inflammatory reaction in brain subjected to CA16 infection. (a) Effects of SAM on virus load in brain. (b) IL-6, IL-8, and CCL-2 levels in serum were detected by the corresponding kits according to the instructions. (b) IL-6, IL-8, and CCL-2 mRNA levels in brain tissues were detected by RT-PCR. (d) P-STAT3, STAT3, and NF-κB were detected in brain tissues by Western blotting. (e) P-STAT3, STAT3, and NF-κB in brain tissues after infection with CA16 for 1, 3, and 7 days. ^##P<0.01 versus control group; ^∗P<0.05; ^∗∗P<0.01 versus model group.

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