Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERK/STAT3/NF-κB Pathway

Figure 5

Effect of SAM on ER stress in brain subjected to CA16 infection. Different groups of 1-day-old BALB/c mice were inoculated i.p. with 2×10⁶ TCID50 of CA16 or with PBS, then SAM were i.p. given for 15 days. CHOP, GRP78, PERK, OASIS, and elF2α expression levels were detected by Western blotting with the corresponding antibodies. (b) and (c) were the statistical results from (a). (d) mRNA levels of CHOP, GRP78, P-PERK, OASIS, and P-elF2α in brain tissues were detected by RT-PCR. (e) Effects of SAM on virus load in brain. ^##P<0.01 versus control group; ^∗P<0.05; ^∗∗P<0.01 versus model group.

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