Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERK/STAT3/NF-κB Pathway

Figure 6

Effect of SAM on CA16 induced cell injury in SH-SY5Y cell. (a) 0–97 mg/mL SAM were given to SH-SY5Y cell for 24 h, and survival rate was detected by MTT. (b) CV16 at the multiplicity of infection (MOI) of 0.5 was used to infect SH-SY5Y cell in the absence or presence of SAM at 0.6, 1.2, or 2.4 mg/mL; survival rate was detected by MTT. (c) LDH was measured by commercial kit and the results were shown as LDH release ratio. IL-6 level was measured by commercial kit as the introduction directed. (e) Cleaved-caspase 3, Bax, and Bcl-2 expression in SH-SY5Y cell were measured by Western blotting. ^##P<0.01 versus control group; ^∗P<0.05; ^∗∗P<0.01 versus model group.

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