Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia

<div>HKII knockdown inhibited glycolysis in TSCC cells. (a) The HKII levels were examined by western blot after 24 h transfection. (b) The expression of HKII for transient transfection of TSCC cells was detected by RT-PCR. (c) The levels of HIF-1<i>α</i>, Glut-1, PFKP, and HKII were measured with western blot after transfection of TSCC cells. (d) Quantitative analysis of HKII was presented. (e) Representative results of glucose consumption were significantly decreased after suppression of HKII. (f) Lactate production was obviously reduced after suppression of HKII. 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BioMed Research International

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Figure 4

Figure 4: Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia 

Figure 4 | Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia 