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BioMed Research International
Volume 2018, Article ID 8503109, 10 pages
https://doi.org/10.1155/2018/8503109
Research Article

Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice

1Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
2Department of Traditional Chinese Medicine, Affiliated Hospital of Nantong University, Nantong, China
3Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China

Correspondence should be addressed to Qing Ye; moc.anis@100gniqeytnsj

Received 27 August 2018; Accepted 25 October 2018; Published 1 November 2018

Academic Editor: Kota V. Ramana

Copyright © 2018 Kun Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease in China. In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) in serum were detected by commercial kits. Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined. In addition, the protein levels of the NF-кB pathway were detected to reveal its mechanism. The results showed that DBD significantly decreased the levels of ALT, AST, CK, and LDH and increased WBCs in CTX-induced mice. In addition, DBD significantly alleviated pathological changes of heart tissue. DBD significantly reduced the protein expressions of NF-кB signaling pathway. In summary, DBD can be considered an effective drug to alleviate CTX-induced heart damage in mice.