Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2018, Article ID 8591397, 12 pages
https://doi.org/10.1155/2018/8591397
Research Article

Involvement of P2X7 Receptor in Proliferation and Migration of Human Glioma Cells

1Department of Neurosurgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
2Department of Head and Neck Surgery, Affiliated Tumor Hospital of Nantong University, Nantong 226001, China
3Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, China
4Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA

Correspondence should be addressed to Min Ji; moc.liamtoh@4321ijyma and Yongping You; nc.ude.umjn@9lpyy

Received 5 September 2017; Revised 22 November 2017; Accepted 29 November 2017; Published 9 January 2018

Academic Editor: Jens Schittenhelm

Copyright © 2018 Zhenhua Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Ma, C. Zheng, E. Bai, and K. Yang, “miR-101 inhibits glioma cell invasion via the downregulation of COX-2,” Oncology Letters, vol. 12, no. 4, pp. 2538–2544, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Mittal, M. C. Szlaczky, and G. R. Barger, “Low-grade gliomas in adults,” Current Treatment Options in Neurology, vol. 10, no. 4, pp. 271–284, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. J. C. L. Alfonso, A. Köhn-Luque, T. Stylianopoulos, F. Feuerhake, A. Deutsch, and H. Hatzikirou, “Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: In silico insights,” Scientific Reports, vol. 6, Article ID 37283, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Grobben, P. P. De Deyn, and H. Slegers, “Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion,” Cell and Tissue Research, vol. 310, no. 3, pp. 257–270, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Zhang, L. Chen, K. Sun et al., “Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression,” Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 37, no. 10, pp. 13777–13788, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Bianchi, M. Vuerich, P. Pellegatti et al., “ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment,” Cell Death & Disease, vol. 5, no. 3, Article ID e1135, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Trabanelli, D. Očadlíková, S. Gulinelli et al., “Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation,” The Journal of Immunology, vol. 189, no. 3, pp. 1303–1310, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Franke, A. Verkhratsky, G. Burnstock, and P. Illes, “Pathophysiology of astroglial purinergic signalling,” Purinergic Signalling, vol. 8, no. 3, pp. 629–657, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Tewari and P. Seth, “Emerging role of P2X7 receptors in CNS health and disease,” Ageing Research Reviews, vol. 24, pp. 328–342, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Pevarello, S. Bovolenta, P. Tarroni et al., “P2X7 antagonists for CNS indications: recent patent disclosures,” Pharmaceutical patent analyst, vol. 6, no. 2, pp. 61–76, 2017. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Stokes, S. J. Spencer, and T. A. Jenkins, “Understanding the role of P2X7 in affective disorders—are glial cells the major players?” Frontiers in Cellular Neuroscience, vol. 9, 258 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Baroja-Mazo, M. Barberà-Cremades, and P. Pelegrín, “The participation of plasma membrane hemichannels to purinergic signaling,” Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1828, no. 1, pp. 79–93, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Jiang, A. Taly, and T. Grutter, “Moving through the gate in ATP-activated P2X receptors,” Trends in Biochemical Sciences, vol. 38, no. 1, pp. 20–29, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. P. A. Verhoef, M. Estacion, W. Schilling, and G. R. Dubyak, “P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1β release,” The Journal of Immunology, vol. 170, no. 11, pp. 5728–5738, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Roger, P. Pelegrin, and A. Surprenant, “Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding,” The Journal of Neuroscience, vol. 28, no. 25, pp. 6393–6401, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Wei, J. K. Ryu, H. B. Choi, and J. G. McLarnon, “Expression and function of the P2X7 receptor in rat C6 glioma cells,” Cancer Letters, vol. 260, no. 1-2, pp. 79–87, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. J. K. Ryu, N. Jantaratnotai, M. C. Serrano-Perez, P. L. McGeer, and J. G. McLarnon, “Block of purinergic P2X7R inhibits tumor growth in a c6 glioma brain tumor animal model,” Journal of Neuropathology & Experimental Neurology, vol. 70, no. 1, pp. 13–22, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Avanzato, T. Genova, A. Fiorio Pla et al., “Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling,” Scientific Reports, vol. 6, Article ID 32602, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Fang, X. Chen, L. Zhang et al., “P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway,” The International Journal of Biochemistry & Cell Biology, vol. 45, no. 6, pp. 1109–1120, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. M. P. Gehring, T. C. B. Pereira, R. F. Zanin et al., “P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line,” Purinergic Signalling, vol. 8, no. 4, pp. 729–739, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Xue, Y. Xie, Y. Xue et al., “Involvement of P2X7 receptors in retinal ganglion cell apoptosis induced by activated Müller cells,” Experimental Eye Research, vol. 153, pp. 42–50, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Braganhol, F. Kukulski, S. A. Lévesque et al., “Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1852, no. 1, pp. 120–130, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. F. B. Morrone, A. P. Horn, J. Stella et al., “Increased resistance of glioma cell lines to extracellular ATP cytotoxicity,” Journal of Neuro-Oncology, vol. 71, no. 2, pp. 135–140, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Li, Y. Cen, Y. Cai et al., “TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cells,” Scientific Reports, vol. 6, Article ID 27104, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Wang, S. Liu, Y. Nie et al., “Activation of P2X7 receptors decreases the proliferation of murine luteal cells,” Reproduction, Fertility and Development, vol. 27, no. 8, pp. 1262–1271, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. Á. Oliveira, P. Illes, and H. Ulrich, “Purinergic receptors in embryonic and adult neurogenesis,” Neuropharmacology, vol. 104, pp. 272–281, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Amoroso, E. Salaro, S. Falzoni et al., “P2X7 targeting inhibits growth of human mesothelioma,” Oncotarget, vol. 7, no. 31, pp. 49664–49676, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Agrawal, Z. Henriksen, S. Syberg et al., “P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts,” Bone, vol. 95, pp. 91–101, 2017. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Le Feuvre, D. Brough, and N. Rothwell, “Extracellular ATP and P2X7 receptors in neurodegeneration,” European Journal of Pharmacology, vol. 447, no. 2-3, pp. 261–269, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Burnstock, “Physiopathological roles of P2X receptors in the central nervous system,” Current Medicinal Chemistry, vol. 22, no. 7, pp. 819–844, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Volonté, S. Apolloni, S. D. Skaper, and G. Burnstock, “P2X7 Receptors: channels, pores and more,” CNS & Neurological Disorders - Drug Targets, vol. 11, no. 6, pp. 705–721, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Burnstock and F. Di Virgilio, “Purinergic signalling and cancer,” Purinergic Signalling, vol. 9, no. 4, pp. 491–540, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Di Virgilio, D. Ferrari, and E. Adinolfi, “P2X7: A growth-promoting receptor - Implications for cancer,” Purinergic Signalling, vol. 5, no. 2, pp. 251–256, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Tan, L. Han, L. Zou et al., “Expression of P2X7R in breast cancer tissue and the induction of apoptosis by the gene-specific shRNA in MCF-7 cells,” Experimental and Therapeutic Medicine, vol. 10, no. 4, pp. 1472–1478, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Giannuzzo, M. Saccomano, J. Napp, M. Ellegaard, F. Alves, and I. Novak, “Targeting of the P2X7 receptor in pancreatic cancer and stellate cells,” International Journal of Cancer, vol. 139, no. 11, pp. 2540–2552, 2016. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Gómez-Villafuertes, P. García-Huerta, J. I. Díaz-Hernández, and M. T. Miras-Portugal, “PI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions,” Scientific Reports, vol. 5, Article ID 18417, 2015. View at Publisher · View at Google Scholar · View at Scopus
  37. A. D. Sadovnick, B. J. Gu, A. L. Traboulsee et al., “Purinergic receptors,” Human Mutation, vol. 38, no. 6, pp. 736–744, 2017. View at Publisher · View at Google Scholar
  38. H. G. Lee, S. M. Won, B. J. Gwag, and Y. B. Lee, “Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of alzheimer's disease,” Experimental & Molecular Medicine, vol. 43, no. 1, pp. 7–14, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Xue, Y. Xie, B. Xue et al., “Activated Müller Cells Involved in ATP-Induced Upregulation of P2X7 Receptor Expression and Retinal Ganglion Cell Death,” BioMed Research International, vol. 2016, Article ID 9020715, 2016. View at Publisher · View at Google Scholar · View at Scopus
  40. E. Adinolfi, M. G. Callegari, D. Ferrari et al., “Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth,” Molecular Biology of the Cell (MBoC), vol. 16, no. 7, pp. 3260–3272, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. S. H. Sun, “Roles of P2X7 receptor in glial and neuroblastoma cells: The therapeutic potential of P2X7 receptor antagonists,” Molecular Neurobiology, vol. 41, no. 2-3, pp. 351–355, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Di Virgilio, “Purines, purinergic receptors, and cancer,” Cancer Research, vol. 72, no. 21, pp. 5441–5447, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. F. Di Virgilio and E. Adinolfi, “Extracellular purines, purinergic receptors and tumor growth,” Oncogene, vol. 36, no. 3, pp. 293–303, 2017. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Falzoni, G. Donvito, and F. Di Virgilio, “Detecting adenosine triphosphate in the pericellular space,” Interface Focus, vol. 3, no. 3, 2013. View at Publisher · View at Google Scholar
  45. J. Masliah-Planchon, S. Garinet, and E. Pasmant, “RAS-MAPK pathway epigenetic activation in cancer: MiRNAs in action,” Oncotarget , vol. 7, no. 25, pp. 38892–38907, 2016. View at Publisher · View at Google Scholar · View at Scopus
  46. T. De Raedt, E. Beert, E. Pasmant et al., “PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies,” Nature, vol. 514, no. 7521, pp. 247–251, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. K. Blagotinšek and D. Rozman, “Targeting signalling pathways in Hepatocellular carcinoma,” Current Pharmaceutical Design, vol. 23, no. 1, pp. 170–175, 2017. View at Publisher · View at Google Scholar · View at Scopus
  48. L. K. Yang, J. Zhu, Y. H. Chen et al., “Knockdown of angiopoietin-like protein 2 inhibits proliferation and invasion in glioma cells via suppressing the ERK/MAPK signaling pathway,” Oncology Research: Featuring Preclinical and Clinical Cancer Therapeutics, vol. 25, no. 8, pp. 1349–1355, 2017. View at Publisher · View at Google Scholar
  49. J. W. Ma, Y. Zhang, J. C. Ye et al., “Tetrandrine exerts a radiosensitization effect on human glioma through inhibiting proliferation by attenuating ERK phosphorylation,” Biomolecules & Therapeutics, vol. 25, no. 2, pp. 186–193, 2017. View at Publisher · View at Google Scholar · View at Scopus
  50. F. Ortega, R. Pérez-Sen, E. G. Delicado, and M. Teresa Miras-Portugal, “ERK1/2 activation is involved in the neuroprotective action of P2Y 13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons,” Neuropharmacology, vol. 61, no. 8, pp. 1210–1221, 2011. View at Publisher · View at Google Scholar · View at Scopus