Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo--D-Glucopyranuronic Acid Compound

Scheme 1

Synthesis of methyl 3-O-phospo-α-D-glucopyranuronic acid (7). Reagents: (a) ZnCl, rt (b) BnBr, NaH, THF, 0C (c) iPr2NP-(OFm)2, 1H-tetrazole, H₂O₂,THF, (d) piperidine, CH₂Cl₂, (e) work-up with buffer, pH 6.0, (f) Et3SiH, 10% Pd/C, MeOH (g) NaOCl, NaOClO, piperidoxyl, acetonitrile, rt, pH 6.9.