Review Article

Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis

Table 1

Characteristics of all studies in meta-analysis.

Authors
(year)
Study design,
Follow-up
No. of participants (defects), gender, age (mean/range), smoking (no, yes, unclear) Intrabony defect degree
Groups, C: control, T: test

Piemontest et al.
(2008)
RCT (parallel)
12 months
60 (60)
Gender: female 29, male 31
Mean age: T , C   
Age range: from 47 to 72
Smoking: no
2 or 3 walls IBDs
C: DFDBA   
T: DFDBA + PRP

Agarwal et al.
(2014)
RCT (split-mouth)
12 months
24 (48)
Gender: female 10, male 14
Mean age: ?
Age range: from 30 to 65
Smoking: no
1 or/and 2 walls IBDs
C: DFDBA   
T: DFDBA + PRP

Jha Kukreja et al.
(2014)
RCT (parallel)
6 months
20 (20)
Gender: female 9, male 11
Mean age: ?
Age range: from 20 to 47
Smoking: no
At least 1 wall IBD
C: DFDBA   
T: DFDBA + PRP

Khospropanah et al.
(2015)
RCT (split-mouth)
6 months
12 (24)
Gender: female 7, male 5
Mean age: 45
Age range: ?
Smoking: no
At least 2 walls IBDs
C: DFDBA   
T: DFDBA + PRP

Bansal et al.
(2013)
RCT (split-mouth)
6 months
10 (20)
Gender: ?
Mean age: ?
Age range: ?
Smoking: no
IBDS: ?
C: DFDBA   
T: DFDBA + PRF

Agarwal et al.
(2016)
RCT (split-mouth)
12 months
30 (60)
Gender: female 14, male 18
Mean age: 52
Age range: ?
Smoking: no
2 or/and 3 walls IBDs
C: DFDBA   
T: DFDBA + PRF ()

Hoidal et al.
(2008)
RCT
6 months
37 (37)
Gender: female 13, male 24
Mean age: ?
Age range: ?
Smoking: yes (7)
1 or/and 2 or/and 3 walls IBDs
C: DFDBA   
T: DFDBA + EMD

Aspriello et al.
(2011)
RCT (parallel)
12 months
56 (56)
Gender: female 34, male 22
Mean age: ?
Age range: from 48 to 62
Smoking: no
2 or 3 walls IBDs
C: DFDBA   
T: DFDBA + EMD

Sali et al.
(2016)
RCT (split-mouth)
12 months
10 (20)
Gender: female 4, male 6
Mean age: ?
Age range: from 25 to 45
Smoking: no
IBDs: ?
C: DFDBA   
T: DFDBA + AM

RCT, randomized controlled trial; C, control; T, test.