Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene

<div>KRAS mutations are associated with poor survival of patients with metastatic tumors other than patients with primary tumors. Log-rank survival curves for overall survival (a) and disease-free survival (b) durations of KRAS mutant (red) and KRAS wild-type (blue) patient in TCGA-PAAD, TCGA-COAD, TCGA-LUAD, and MSKCC-IMPACT cohorts. Metastatic cancer with KRAS mutation showed significantly reduced overall survival compared with their KRAS wild-type counterparts.</div>

BioMed Research International

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Figure 2: Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene 

Figure 2 | Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene 