Resveratrol Inhibits the TGF-β1-Induced Proliferation of Cardiac Fibroblasts and Collagen Secretion by Downregulating miR-17 in Rat

Figure 2

The effect of resveratrol on TGF-β1-induced cardiac fibroblast proliferation and collagen secretion. (a) Representative images. All cell nuclei were stained with Hoechst33342 (blue). The proliferating cell nuclei were stained with 1×Apollo® Staining Solution (red). C: control; T: TGF-β1; T+R: TGF-β1+RSV. (b) The relative ratio of EdU-positive cells. (c) The CF proliferation rate as assessed by CCK-8 assay. (d) The secretion of hydroxyproline as measured using the hydroxyproline assay kit. P<0.001 versus the control group and ###P<0.001 versus the TGF-β1 group (n=3).

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