Review Article

Protocol for Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included cohort studies of FMT in IBD.

StudytypenAge(y)SeverityRouteDonorFresh/FrozenClinical response Clinical remissionFollow-up (months)

Angelberger et al [18] (2013)UC522-51moderate-severenasojejunal tube and enemaidentified but first degree relatives excludedFresh103
Kunde et al [19].(2013)UC107-21mild-moderatecolonoscopyfamily members or close friendsFresh631
Kump et al [20].(2013)UC617-52moderate-severeenemaunrelatedFrozen203
Cui et al [21] a (2015)UC1511-48moderate-severegastroscopehealthy children (patient relatives or friends)Frozen1244-72
Damman et al [22] (2015)UC727-61mild-moderatecolonoscopyfamily members or close friendsFresh113
Ren et al [23] (2015)UC717-66severeColonoscopy and gastroscopyfamily members or unrelatedFresh771-7
Scaldaferri et al [24].(2015)UC830-44mild-moderatecolonoscopyunrelatedNR433
Wei al et [25] a(2015)UC/CD1416-70mild-moderateunrelatedFrozen961
Suskind et al [26] a.(2015)UC413-16mild-moderatenasogastricNRFresh003
Vermeire et al [27].(2016)UC/CD14(8/6)28-53moderate-severe, refractory, failed immunotherapy and anti-TNFNasojejunal or rectalfamily members or close friendsFresh222
Nishida et al [28].(2017)UC41mild-moderatecolonoscopyfamily membersFresh1102
Wei et al [29] b (2016)UC2018-70mild-moderatecolonoscopyunrelatedFresh1373
Ishikawa et al [30] (2017)UC1721-65mild-to-severe activecolonoscopyfamily membersFresh1491
Zhang et al [31] (2016)UC1919-60moderate-severegastroscopeNRFresh112≥3
Karakan et al [32].(2016)UC14NRSteroid-dependentcolonoscopyNRNR1163-18
Goyal et al [33].(2016)UC/CD16(12/4)<18mild-moderategastroscopeNRFresh526
Kellermayer et al [34] (2015)UC314-16immunotherapy dependentcolonoscopy and enemaunrelatedFrozen333
Karolewska-Bochenek et al [35] (2015)UC410-17mild-moderategastroscopeunrelatedNR401
Cui et al [36] b.(2015)CD3015-71moderate-severegastroscopefamily members or close friends or unrelated23 Fresh 7 Frozen20186-15
Suskind et al [37] b (2015)CD912-19mild-moderatenasogastricfamily members(parents)Fresh753
Vaughn et al [38].(2016)CD19activecolonoscopyunrelated11106.5
Zhang et al [39].(2013)CD1614-63refractorygastroscopeNRFrozen1231
Alka-Goyal etal [40],(2018)UC/CD21(14/7)8-21refractorycolonoscopy and gastroscopyfamily members or close friendsFresh626

UC: ulcerative colitis; CD: Crohn’s disease; NR: no report.