Protocol for Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Table 2

Prevalence in different subgroups.

Stratification group	Number of studies	Number	Events	I^2	p value	Prevalence	95% CI
Current prevalence	23	319	93	86%	<0.01	0.27	0.15-0.41
Subtype
UC	19	225	53	88%	<0.01	0.21	0.08-0.38
CD	8	94	40	75%	<0.01	0.3	0.13-0.52
Populations
Paediatric UC	6	47	6	85%	<0.01	0.1	0.00-0.43
Adult UC	13	178	45	88%	<0.01	0.26	0.10-0.48
Paediatric CD	3	20	9	0%	0.53	0.45	0.24-0.66
Adult CD	5	74	31	85%	<0.01	0.22	0.03-0.52
Preparation of inoculum
Fresh for UC	12	164	31	89%	<0.01	0.15	0.03-0.37
Frozen for UC	4	35	13	87%	<0.01	0.42	0.05-0.86
Fresh for CD	5	49	24	78%	<0.01	0.36	0.10-0.68
Frozen for CD	4	45	16	69%	0.02	0.28	0.07-0.55
Route of administration
Upper GI for UC	4	42	6	51%	0.10	0.08	0.00-0.26
Lower GI for UC	10	137	38	88%	<0.01	0.31	0.11-0.57
Upper GI for CD	5	63	26	83%	<0.01	0.23	0.02-0.55
Lower GI for CD	2	20	10	60%	0.11	0.27	0.00-0.93
Disease severity
Mild-moderate	9	129	27	84%	<0.01	0.20	0.06-0.41
Moderate-severe	11	133	45	83%	<0.01	0.30	0.10-0.54
pre-antibiotic treatment or not
Pretreatment	7	85	29	73%	<0.01	0.25	0.09-0.46
Un-pretreatment	16	234	64	89%	<0.01	0.28	0.13-0.47