Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model

Figure 4

Combination of t-PA and PCB improves long-term behavior outcomes. PCB was administrated every 24 hr for 7 d after the combination therapy at 6 hr after thromboembolic stroke. (a) Neurological deficits test, (b) forelimb function test, (c) rotating rod test, and (d) inclined plane test were examined after the combination therapy at 6 hr after thromboembolic stroke in thromboembolic stroke rats. versus thromboembolic stroke treated with t-PA; versus thromboembolic stroke treated with vehicle saline. Data are expressed as the mean ± SEM (). (e) Mortality rates were 70% (7/10) in saline-treated rats and 90% (9/10) in the delayed t-PA treatment group, whereas therapy with PCB + t-PA reduced mortality to 30% (3/10) at 7 d after reperfusion ( = 10, < 0.05 versus t-PA, test). (f) Body weights were recorded and the rebound points were compared. versus thromboembolic stroke treated with t-PA; versus thromboembolic stroke treated with vehicle saline. Data are all expressed as the mean ± SEM.

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