Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model

Figure 6

PCB reduced the permeability of BBB model in vitro by inhibiting the PDGF-CC/PDGFRα signaling pathway. (a) Western blot analysis of phosphorylated PDGFRα in cell membrane with different treatments. (b) Schematic of BBB model in vitro by using the Transwell insert. The permeability of BBB model was tested during 6 h of hypoxia/aglycemia and 2 h of reperfusion. (c-d) The contents of PDGF-CC in the culture medium of CTXTNA2 and cerebEND cells ( = 3; < 0.05, versus t-PA; versus vehicle saline).

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