In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network

Table 3

31 potential reactions for drug targets in Plasmodium falciparum from this study.

S/N	Reaction	Gene ID	Common name	EC number
	CATAL-RXN	ORPHAN	Catalase	1.11.1.6
	RXN-1321	ORPHAN	Linoleate 13S-lipoxygenase	1.13.11.12
	12-OXOPHYTODIENOATE-REDUCTASE-RXN	ORPHAN	12-Oxophytodienoate reductase	1.3.1.42
	RXN0-1461	PF11_0436	Coproporphyrinogen oxidase	1.3.3.3
	AICARTRANSFORM-RXN	ORPHAN	Phosphoribosylaminoimidazolecarboxamide formyltransferase	2.1.2.3
	METHYLACETOACETYLCOATHIOL-RXN	PF14_0484	Acetyl-CoA C-acetyltransferase	2.3.1.9
	S-ADENMETSYN-RXN	PFI1090W	Methionine adenosyltransferase	2.5.1.6
	OHMETHYLBILANESYN-RXN	PFL0480W	Hydroxymethylbilane synthase	2.5.1.61
	ACETYLORNTRANSAM-RXN	PFF0435W	Acetylornithine transaminase	2.6.1.11
	2.6.1.18-RXN	PFF0435W	β-Alanine—pyruvate transaminase	2.6.1.18
	PABASYN-RXN	PFI1100W	Aminodeoxychorismate synthase	2.6.1.85
	SHIKIMATE-KINASE-RXN	ORPHAN	Shikimate kinase	2.7.1.71
	UDPKIN-RXN	ORPHAN	Nucleoside-diphosphate kinase	2.7.4.6
	DTMPKI-RXN	PFL2465C	dTMP kinase	2.7.4.9
	H2PTERIDINEPYROPHOSPHOKIN-RXN	PF08_0095	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	2.7.6.3
	NICONUCADENYLYLTRAN-RXN	PF13_0159	Nicotinate-nucleotide adenylyltransferase	2.7.7.18
	NAG1P-URIDYLTRANS-RXN	MAL13P1.218	UDP-N-acetylglucosamine diphosphorylase	2.7.7.23
	GLUC1PURIDYLTRANS-RXN	MAL13P1.218	UTP—glucose-1-phosphate uridylyltransferase	2.7.7.9
	2.7.8.15-RXN	PFC0935C	UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase	2.7.8.15
	RXN-6384	PFL1940W	3-Hydroxyisobutyryl-CoA hydrolase	3.1.2.4
	3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN	PFL1940W	3-Hydroxyisobutyryl-CoA hydrolase	3.1.2.4
	IMPCYCLOHYDROLASE-RXN	ORPHAN	IMP cyclohydrolase	3.5.4.10
	GTP-CYCLOHYDRO-I-RXN	PFL1155W	GTP cyclohydrolase I	3.5.4.16
	UROGENDECARBOX-RXN	PFF0360W	Uroporphyrinogen decarboxylase	4.1.1.37
	ADCLY-RXN	PFI1100W	Aminodeoxychorismate lyase	4.1.3.38
	PORPHOBILSYNTH-RXN	PF14_0381	Porphobilinogen synthase	4.2.1.24
	UROGENIIISYN-RXN	ORPHAN	Uroporphyrinogen-III synthase	4.2.1.75
	RXN1F-19	ORPHAN	Hydroperoxide dehydratase	4.2.1.92
	ALLENE-OXIDE-CYCLASE-RXN	ORPHAN	Allene-oxide cyclase	5.3.99.6
	TRYPTOPHAN--TRNA-LIGASE-RXN	PF13_0205, PFL2485C	Tryptophan—tRNA ligase	6.1.1.2
	HISTIDINE--TRNA-LIGASE-RXN	PF14_0428	Histidine—tRNA ligase	6.1.1.21