Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome

Figure 2

Differential long RNA expression and mRNA-miRNA interaction network. (a) Visualization of differentially expressed long RNAs by floating bars depicting the range of normalized counts from minimal to maximal values within in the respective groups. Black lines within the boxes represent the median. Red boxes show counts for transcripts of patients with uncontrolled diabetes mellitus, blue boxes show values of control patients. Underlined genes were also differentially expressed by analysis with edgeR-QLF, either after duplicate removal with picard (single line) or also with SAMtools (double line). (b) Genome browser view for transcripts of the MACF1 gene. Transcripts of patients with uncontrolled diabetes mellitus are shown in red, transcripts of control patients in blue. FPKM denotes fragments per kilobase of transcript per million mapped reads. (c) Visualization of predicted mRNA-miRNA interactions obtained by analysis with Magia [2]. mRNAs are depicted by blue circles, miRNAs by orange triangles. Upregulation of mRNAs or miRNAs in uncontrolled diabetes mellitus is shown in red, downregulation in blue. The predicted direction of interaction is represented by the color of the arrows.

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