Mutational Profiling of Non-Small-Cell Lung Cancer Resistant to Osimertinib Using Next-Generation Sequencing in Chinese Patients

Table 2

Mutation types and mutant allele fraction (MAF) (%).

#1		#2		#3		#4		#5		#6		#7		#8		#9
Mutation	Rate	Mutation	Rates	Mutation	Rates	Mutation	Rates	Mutation	Rates	Mutation	Rates	Mutation	Rates	Mutation	Rates	Mutation	Rates
L858R	63.2	19 del	48.6	19 del	2.8	L858R	22.2	19 del	2.1	19 del	85.5	19 del	51.9	19 del	24.3	19 del	65.68
IL7R	31.5	T790M	15.1	T790M	4.6	T790M	2.2	PIK3CA	1.8	T790M	61.5	T790M	32.5	T790M	18.7	T790M	46.04
TENM3	27.1	JAK1	13.7	C797G	2.6	NOTCH3	27.5	TP53	1.7	C797G	36.6	C797S T>A	18.4	C797S T>A	6	C797S G>C	11.4
CCND3	14.3	NF2	11.4	EML4-ALK	0.9	IGF1R	15.1	RNASEL	1.2	EGFR 834>L	91.1	C797S G>C	0.8	C797S G>C	5	TP53	35.62
ROS1 (6737 G>A)	2.9	TET2	10.5	PIK3CA	0.9	ZNF512B	10.5	TET2	0.8	TP53	85.2	EGFR2134T>A	0.3	C797G	2.2	C11orf30	17.1
FGFR3	1.9	FCGR2A	18.1			TMPRSS2	10.5	MAP3K1	0.8			TP53	36.7	CTNNB1	38.8	FLT4	12.01
XPC	1.5					MLL3	7.8					RB1	20.5	MED12	34.8
ATM	1.5					PIK3CB	6.7					PIK3CA	0.7	APC	21.9
FAM135B	1.2					EGFR L406Q	6.6					BRCA1	0.6	SCF1R	4.6
PALB2	1.1					FLT4	4.9					ALK	0.6	FCGR2R	2.5
MLL	1					ERBB3	3.3					JAK1	0.5
ROS1 (1611A>G)	1					FAT1	3.2					ROS1 2495T>A	0.4
CDKN2A	0.2					HPS3	3.2
Altered copy						GNAS	2.5
CDKN2B DEL	0.3					CLB	2.2
CDKN2A DEL	0.2					CDKN1A	1.9
						SMO	1.9
						ROBO3	1.7
						PTCH1	1.7
						CDK12	1.4
						MDM2	1.2
						FOXL2	1.1
						Amplification
						MDM2	3.8
						CDK4	5.0