Adoptive Transfers of CD4⁺CD25⁺ Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis

Figure 2

Adoptive transfer of Tregs induces an inflammatory response in ETEC K88-infected mice. Mice infected with ETEC K88, either with transferred Tregs or not, were euthanized. (a) Weight change. (b) Disease activity score (DAS). (c-f) Duodenum was obtained and histological studies were carried out using H&E staining (200×). Representative images from mice that were (c) uninfected, (d) from the enteritis group, (e) after transfer at 72 h, and (f) from the Treg-inhibiting group. Representative data from 3 independent experiments is shown. Six mice per group were used in the study. (g) The levels of IL-1β, TNF-α, NO, and PGE2 in the peripheral blood. p<0.05 and p<0.01 compared with the corresponding enteritis group, one-way ANOVA.

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