Eosinophils from Physiology to Disease: A Comprehensive Review

Table 3

Diagnostic criteria for DRESS.

RegiSCAR criteria (three or more required)	J-SCAR (seven or more required):
(i) Hospitalization; (ii) Reaction suspected to be drug related; (iii) Fever > 38°C; (iv) Acute skin rash; (v) Hematologic abnormalities (eosinophilia, atypical lymphocytosis, low platelets); (vi) Lymphadenopathy; (vii) Internal organ involvement	(i) Maculopapular rash developing > 3 weeks after drug exposure; (ii) Prolonged clinical symptoms after discontinuation of the causative drug; (iii) Fever > 38°C; (iv) Liver abnormalities (ALT > 100 U/l) or other organ involvement; (v) Lymphadenopathy; (vi) WBC abnormalities (≥1); (vii) Leukocytosis; (viii) Atypical lymphocytes; (ix) Eosinophilia; (x) HHV-6 reactivation