Osteopontin Expression Is Associated with the Poor Prognosis in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy

Figure 3

Endogenous osteopontin depletion by osteopontin siRNA sensitized the cytotoxicity to cisplatin in esophageal squamous cell carcinoma cell lines. (a) The endogenous expression level of osteopontin was determined by western blotting in TE10 and TE14 cells transfected with si-Control or si-Osteopontin. (b) TE10 and TE14 cells transfected with si-Control or si-Osteopontin were incubated with 10 μM cisplatin for 48 hours, and their viability was measured and compared to that of untreated respective cells. OPN: osteopontin. ; ; .

(a)

(b)