Osteopontin Expression Is Associated with the Poor Prognosis in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy

Table 4

Results of univariate log-rank analysis of prognostic factors for overall survival and disease-free survival in 80 patients with locally advanced esophageal squamous cell carcinoma receiving preoperative chemoradiotherapy.

Factors	Number of patients	Overall survival (OS)		Disease-free survival (DFS)
		5-year OS rate (%)	value	5-year DFS rate (%)	value
Age
<53 y/o	39	26%	0.73	21%	0.56
≧53 y/o	41	29%		25%
Osteopontin
Low expression	42	33%	0.017	31%	0.038
Overexpression	38	21%		13%
Clinical 7th AJCC stage
II	21	43%	0.13	29%	0.27
III	59	22%		21%
Clinical T classification
T2/3	43	35%	0.024	28%	0.035
T4	37	19%		16%
Clinical N classification
N0	20	35%	0.46	25%	0.70
N1/2/3	60	25%		22%
Clinical N classification
N0/1	45	33%	0.064	25%	0.15
N2/3	35	20%		20%
Tumor grade
Grade 1/2	59	25%	0.40	19%	0.38
Grade 3	21	33%		33%
Primary tumor location
Upper/middle	46	28%	0.61	23%	0.60
Lower	34	27%		23%

pCR, pathological complete response. Statistically significant.