Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2018, Article ID 9136208, 9 pages
Clinical Study

Temporal Change of Interleukin-6, C-Reactive Protein, and Skin Temperature after Total Knee Arthroplasty Using Triclosan-Coated Sutures

1Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan
2Chang Gung University, Taoyuan, Taiwan
3Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan
4Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan
5Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Correspondence should be addressed to Tsan-Wen Huang; wt.gro.hmgc@1801068b and Mel S. Lee; moc.rotcod@enob

Received 31 August 2017; Revised 20 November 2017; Accepted 29 November 2017; Published 15 January 2018

Academic Editor: Carla Renata Arciola

Copyright © 2018 Shih-Jie Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The risk of surgical site infections (SSIs) after total knee arthroplasty (TKA) can never be eliminated. Antimicrobial sutures containing triclosan have been used to decrease SSIs, but whether triclosan-coated sutures are effective with TKA is unclear. Between 2011 and 2012, 102 patients randomly assigned to a triclosan or a control group were prospectively assessed. The incidence of SSI within 3 months of surgery, length of hospital stay, pain scale, functional scores, wound condition, and serum inflammatory markers during hospitalization and within 3 months postoperatively were compared. At the final follow-up, there were 2 patients with superficial infections (3.9%) in the control group but none in the triclosan group. Lower serum IL-6 was detected in the triclosan group at 4 weeks and 3 months. The local skin temperature of the knees—recorded at 3 months using infrared thermography—was lower in the triclosan group than in the control group. More precise analytical measurements are needed to investigate local and systemic complications, especially in the early subclinical stage. This prospective, randomized, open-label clinical trial is in the public registry: (NCT02533492).