PER1-deficient mice: normal bone volume [91] PER2-deficient mice: normal bone volume [91] PER2 PAS domain (): normal bone volume [91] PER1−/−;: significantly increased bone mass [91] PER1-/-; PER2-/-: increased bone mass [91] mice: increased bone volume at 3, 12 and 48 weeks [92]
CRYs
CRY1-deficient mice: circadian period 1 hour shorter than wild type [93, 94] CRY2-deficient mice: circadian period 1 hour longer than wild type [95] CRY1/2 double knockout mice: arrhythmic in constant darkness [121]
CRY1-deficient mice: not reported CRY2-deficient mice: increased bone volume [94] CRY1/2 double knockout mice: high bone volume [91]
REV-ERBs
REV-ERBα knockout: average period length significantly shorter [122] REV-ERBβ knockout: no changes in circadian activity rhythms [123] REV-ERBα/β double knockout: the free running period length in constant darkness was 2.5 hours shorter [123]
REV-ERBα knockout: not reported REV-ERBβ knockout: not reported REV-ERBα/β agonist SR9009: suppressed osteoclast formation and ameliorated OVX-induced bone loss [17]
RORs
RORα (sg/sg): shortened period length of the locomotor activity rhythm [102] RORβ knockout: significant increase in circadian period in constant dark [103]
RORα (sg/sg): osteopenic [104] RORβ knockout: increase bone mass [108]
DECs
DEC1 knockout: longer circadian period under conditions of constant darkness [109] DEC2 knockout: no changes in circadian activity rhythms [110]