Optimizing Livers for Transplantation Using Machine Perfusion versus Cold Storage in Large Animal Studies and Human Studies: A Systematic Review and Meta-Analysis

Figure 4

Forest plots comparing biliary complications and EAD for all studies comparing different MP to CS in human studies. (a) Biliary complications. NMP cannot reduce the biliary complications (RR: 1.08, 95% CI: 0.41 to 2.85); HMP reduced the biliary complications (RR: 0.45, 95% CI: 0.28 to 0.73); (b) EAD. NMP reduced the EAD (RR: 0.74, 95% CI: 0.24 to 2.34) and HMP reduced the EAD (RR: 0.56, 95% CI: 0.34 to 0.92). MP: machine perfusion; HMP: hypothermic machine perfusion; NMP: normothermic machine perfusion; CS: cold static storage; SMD: standardized mean differences; RR: relative risk; CI: confidence interval; EAD: early allograft dysfunction.

(a)

(b)