Optimizing Livers for Transplantation Using Machine Perfusion versus Cold Storage in Large Animal Studies and Human Studies: A Systematic Review and Meta-Analysis

Figure 5

Forest plots comparing PNF and graft survival for all studies comparing different MP to CS in human studies. (a) PNF. HMP reduced the PNF (RR: 0.37, 95% CI: 0.06 to 2.35), while NMP increased the PNF (RR: 2.51, 95% CI: 0.10 to 60.91); (b) graft survival. NMP cannot improve the graft survival (RR: 0.99, 95% CI: 0.95 to 1.04), while HMP improved the graft survival (RR: 1.12, 95% CI: 0.93 to 1.35). MP: machine perfusion; HMP: hypothermic machine perfusion; NMP: normothermic machine perfusion; CS: cold static storage; PNF: primary nonfunction; RR: relative risk; CI: confidence interval.

(a)

(b)