Optimizing Livers for Transplantation Using Machine Perfusion versus Cold Storage in Large Animal Studies and Human Studies: A Systematic Review and Meta-Analysis

Table 2

Quality of animal studies included in this analysis using SYRCLE’s risk of bias tool for animal studies.

Author( year)	(1)	(2)	(3)	(4)	(5)	(6)	(7)	(8)	(9)	(10)
Iwamoto; (2000)	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No	Unclear
Michael; (2001)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes	Unclear
Brockmann; (2009)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes	Unclear
Fondevila; (2011)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes	Unclear
Monbaliu; (2011)	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes	Unclear
Fondevila; (2012)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Unclear	No	Unclear
Knaak; (2014)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	No	No	Unclear
Fontes; (2015)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No	Unclear
Spetzler; (2016)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	No	Yes	Unclear
Zhibin Zhang; (2016)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	No	Yes	Unclear
Goldaracena; (2016)	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	No	Yes	Unclear

Study quality items are (1) adequate sequence generation; (2) similar baseline characteristics for study groups; (3) allocation concealment present; (4) random housing utilised; (5) blinding of investigators; (6) all animals selected for outcome assessment; (7) blinding of outcome assessor(s); (8) incomplete outcome data addressed; (9) outcome reporting not selective; (10) other sources of bias present.