Chemokine C-C Motif Ligand 4 Gene Polymorphisms Associated with Susceptibility to Rheumatoid Arthritis
Table 2
Polymorphism frequencies among the study participants.
SNPs
Controls
RA patients
OR (95% CI)
AOR (95% CI)
(N=371)
(N=217)
rs10491121
A/A
94 (25.3%)
54 (24.9%)
1.00
1.00
A/G
175 (47.2%)
105 (48.4%)
1.04 (0.69-1.58)
0.82 (0.53-1.28)
G/G
102 (27.5%)
58 (26.7%)
0.99 (0.62-1.58)
0.91 (0.56-1.49)
A/G+G/G
277 (77.7%)
163 (75.1%)
1.02 (0.70-1.51)
0.85 (0.56-1.27)
rs1719153
A/A
162 (43.7%)
80 (36.9%)
1.00
1.00
A/T
164 (44.2%)
108 (49.8%)
1.33 (0.93-1.91)
0.67 (0.46-0.99)#
T/T
45 (12.1%)
29 (13.4%)
1.31 (0.76-2.24)
0.77 (0.44-1.35)
A/T+T/T
209 (56.3%)
137 (63.2%)
1.33 (0.94-1.87)
0.69 (0.48-0.99)#
rs1634507
C/C
161 (43.4%)
90 (41.5%)
1.00
1.00
A/C
165 (44.5%)
98 (45.2%)
1.06 (0.74-1.52)
0.81 (0.55-1.19)
A/A
45 (12.1%)
29 (13.4%)
1.15 (0.68-1.97)
0.89 (0.51-1.57)
A/C+A/A
210 (56.6%)
127 (58.6%)
1.08 (0.77-1.52)
0.83 (0.58-1.19)
Data are represented as N (%). #p< 0.05. SNP: single nucleotide polymorphism; RA: rheumatoid arthritis; OR: odds ratio; CI: confidence interval; AOR: adjusted odds ratio.
