Neutrophilic Asthma Is Associated with Increased Airway Bacterial Burden and Disordered Community Composition

Table 2

Cytokines in supernatant of sputum samples from subjects with NA and non-NA.

Cytokines	Comparison between groups			Spearman’s correlation
	NA	Non-NA	P	Rho	P
IL-1β, pg/ml	515.4 (226.4, 1523.9)	192.1 (69.3, 527.1)	0.010	0.511	<0.001
IL-6, pg/ml	1410.5 (633.6, 3395.1)	419.7 (290.6, 1312.8)	0.031	0.277	0.042
IL-8, mg/ml	49.9 (28.1, 54.4)	28.7 (6.9, 48.1)	0.015	0.476	<0.001
IL-12, pg/ml	2.3 (2.0, 4.3)	1.5 (1.1, 2.2)	0.002	0.541	<0.001
IL-17A, pg/ml	4.3 (2.2, 10.8)	2.9 (1.4, 4.1)	0.021	0.513	<0.001
TNF-α, pg/ml	313.5 (119.0, 1046.3)	180.1 (90.5, 317.9)	0.032	0.454	0.001

Data are presented as median (quartile 1, quartile 3) unless otherwise indicated. Significant differences between groups were determined by using Mann–Whitney U test. Correlation coefficients between cytokines and neutrophil percentage were calculated by Spearman’s correlation.
NA: neutrophilic asthma; IL: interleukin; TNF: tumor necrosis factor.