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BioMed Research International
Volume 2018 (2018), Article ID 9241679, 7 pages
https://doi.org/10.1155/2018/9241679
Research Article

Epidemiological Profile and Risk Factors for Acquiring HBV and/or HCV in HIV-Infected Population Groups in Nepal

1Kathmandu Research Institute for Biological Sciences, Lalitpur, Nepal
2National Public Health Laboratory, Teku, Kathmandu, Nepal
3Virology Units, Central Department of Biotechnology, Tribhuvan University, Kirtipur, Kathmandu, Nepal
4Sagarmatha Diagnostic Centre, Nepalgunj, Banke, Nepal
5Ayurveda Campus, TU, Kirtipur, Kathmandu, Nepal
6Department of Biomedical Sciences, Oregon State University, Corvallis, OR, USA

Correspondence should be addressed to Birendra Prasad Gupta

Received 13 July 2017; Accepted 2 November 2017; Published 2 January 2018

Academic Editor: Naveed Janjua

Copyright © 2018 Manjula Bhattarai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

HBV and HCV infections are widespread among the HIV-infected individuals in Nepal. The goals of this study were to investigate the epidemiological profile and risk factors for acquiring HBV and/or HCV coinfection in disadvantaged HIV-positive population groups in Nepal. We conducted a retrospective study on blood samples from HIV-positive patients from the National Public Health Laboratory at Kathmandu to assay for HBsAg, HBeAg, and anti-HCV antibodies, HIV viral load, and CD4+ T cell count. Among 579 subjects, the prevalence of HIV-HBV, HIV-HCV, and HIV-HBV-HCV coinfections was 3.62%, 2.93%, and 0.34%, respectively. Multivariate regression analysis indicated that spouses of HIV-positive migrant labourers were at significant risk for coinfection with HBV infection, and an age of >40 years in HIV-infected individuals was identified as a significant risk factor for HCV coinfection. Overall our study indicates that disadvantaged population groups such as intravenous drug users, migrant workers and their spouses, female sex workers, and men who have sex with HIV-infected men are at a high and persistent risk of acquiring viral hepatitis. We conclude that Nepalese HIV patients should receive HBV and HCV diagnostic screening on a regular basis.