Association between VEGF Gene Polymorphisms and the Susceptibility to Lung Cancer: An Updated Meta-Analysis

Table 3

Meta-analysis results for the included studies of the association between rs3025039, rs833061, and rs699947 polymorphisms and risk of lung cancer.

Variables	No. of studies	Dominant model			Recessive model			Homozygous model			Heterozygous model			Allele model
		OR (95% CI)	P values	I-squared (%)	OR (95% CI)	P values	I-squared (%)	OR (95% CI)	P values	I-squared (%)	OR (95% CI)	P values	I-squared (%)	OR (95% CI)	P values	I-squared (%)
rs3025039 C>T	+936C/T	(CT + TT) vs. CC			TT vs. (CT + CC)			TT vs. CC			CT vs. CC			T vs. C
All	9	1.12 (0.87-1.46)	<0.001	76.4	1.25 (0.94-1.65)	0.266	19.9	1.32(0.86-2.04)	0.047	48.9	1.11 (0.86-1.42)	<0.001	72.1	1.11 (0.89-1.38)	<0.001	76.2
Ethnicity
Asian	6	1.17 (0.75-1.81)	<0.001	84.4	1.37 (0.95-1.97)	0.154	37.9	1.47 (0.78-2.77)	0.022	61.9	1.14 (0.74-1.75)	<0.001	82	1.15(0.81-1.65)	<0.001	83.8
Caucasian	3	1.07 (0.92-1.23)	0.681	0	1.10 (0.70-1.70)	0.507	0	1.11 (0.71-1.73)	0.488	0	1.07 (0.92-1.24)	0.836	0	1.06 (0.93-1.21)	0.522	0
Source of control
HB	3	1.07 (0.92-1.23)	0.681	0	1.10 (0.70-1.70)	0.507	0	1.11 (0.71-1.73)	0.488	0	1.07(0.92-1.24)	0.836	0	1.06 (0.93-1.21)	0.522	0
PB	6	1.17 (0.75-1.81)	<0.001	84.4	1.37 (0.95-1.97)	0.154	37.9	1.47 (0.78-2.77)	0.022	61.9	1.14 (0.74-1.75)	<0.001	82	1.15(0.81-1.65)	<0.001	83.8
rs833061 C>T	-460C/T	(CT + TT) vs. CC			TT vs. (CT + CC)			TT vs. CC			CT vs. CC			T vs. C
All	6	1.11(0.97-1.27)	0.534	0	1.02(0.92-1.13)	0.151	38.2	1.12 (0.96-1.30)	0.269	21.9	1.11 (0.96-1.28)	0.687	0	1.04 (0.97-1.12)	0.201	31.2
Ethnicity
Asian	4	1.42 (1.07-1.90)	0.991	0	1.09 (0.94-1.27)	0.085	54.6	1.51 (1.12-2.03)	0.821	0	1.34 (0.99-1.81)	0.837	0	1.12 (1.00-1.26)	0.184	38
Caucasian	2	1.03 (0.88-1.20)	0.721	0	0.96 (0.83-1.11)	0.684	0	1.00 (0.83-1.20)	0.991	0	1.05 (0.89-1.24)	0.616	0	0.99 (0.91-1.09)	0.957	0
Source of control
HB	3	1.05 (0.91-1.22)	0.531	0	0.98 (0.86-1.11)	0.807	0	1.03 (0.87-1.23)	0.532	0	1.07 (0.92-1.26)	0.554	0	1.01 (0.93-1.10)	0.757	0
PB	3	1.45 (1.03-2.06)	0.968	0	1.11 (0.93-1.33)	0.039	69.1	1.59 (1.11-2.29)	0.708	0	1.33 (0.92-1.91)	0.656	0	1.14 (0.99-1.31)	0.095	57.5
rsrs699947 C>A	-2578C/A	(CA + AA) vs. CC			AA vs. (AA + CC)			AA vs. CC			AA vs. CC			A vs. C
All	7	1.33(0.74-2.40)	<0.001	91.8	0.98(0.52-1.84)	<0.001	78	1.15(0.71-1.86)	0.037	55.1	1.33 (0.66-2.68)	<0.001	93.7	1.12 (0.87-1.43)	<0.001	77.2
Ethnicity
Asian	5	1.53 (0.67-3.51)	<0.001	94.3	1.15(0.37-3.52)	<0.001	84.9	1.50(0.71-3.20)	0.026	63.9	1.48(0.54-4.04)	<0.001	95.7	1.22 (0.87-1.70)	<0.001	80.6
Caucasian	2	0.94(0.68-1.31)	0.654	0	0.79(0.55-1.13)	0.417	0	0.79 (0.52-1.22)	0.426	0	1.01(0.72-1.42)	0.842	0	0.90 (0.74-1.11)	0.434	0
Source of control
HB	3	1.15 (0.75-1.77)	0.122	52.6	0.83 (0.59-1.18)	0.411	0	0.93 (0.56-1.54)	0.247	28.6	1.19(0.82-1.73)	0.224	33.2	1.05 (0.76-1.45)	0.073	61.8
PB	4	1.45(0.54-3.90)	<0.001	95.6	1.09 (0.27-4.34)	<0.001	88.2	1.43 (0.58-3.54)	0.017	70.4	1.39 (0.42-4.65)	<0.001	96.7	1.15 (0.79-1.69)	<0.001	84.3