The Plant Proteinase Inhibitor CrataBL Plays a Role in Controlling Asthma Response in Mice

Figure 1

Timeline of experimental design. OVA and OVA+CR groups received OVA (50 μg i.p.) + Alum (6 mg) on days 0 and 14, and on days 22, 24, 26, and 28 they were exposed to nebulized OVA aerosol. C and C+CR groups received only Alum i.p. on days 0 and 14, and on days 22, 24, 26, and 28 they received saline inhalations. C+CR and OVA+CR groups received treatment with CrataBL (2 mg/Kg i.p.) once daily (from day 22 to day 28; on inhalation days CrataBL was administered two hours after inhalation). On day 29, respiratory lung mechanics were assessed in all groups. Two independent experiments were conducted (n=8 per group per experiment).