The Plant Proteinase Inhibitor CrataBL Plays a Role in Controlling Asthma Response in Mice

Table 2

Absolute values of morphometric and optical density measurement analysis for inflammatory, remodeling, and oxidative stress markers in the airways. Eight animals per group were used in these analyses. P<0.05 compared to OVA+CR, C, and C+CR groups; † P<0.05 compared to C and C+CR groups.

Inflammatory Markers	C	OVA	C+CR	OVA+CR
Eosinophils (cells/10^4m^2)	0.23±0.14	19.72±1.34	0.14±0.14	6.24±1.31 †
IL-4 (cells/10^4m^2)	2.19±0.10	21.74±2.08	1.19±0.78	9.49±0.93 †
IL-5 (cells/10^4m^2)	0.62±0.40	19.82±1.47	0.74±0.74	7.88±0.67 †
IL-13 (cells/10^4m^2)	2.19±0.47	23.18±1.92	1.47±0.74	4.82±0.61
IL-17 (cells/10^4m^2)	1.04±0.30	7.83±0.70	1.33±0.23	2.63±0.33†
IFN- (cells/10^4m^2)	1.64±0.68	16.39±1.22	1.30±0.61	6.02±1.21 †
Remodeling Markers	C	OVA	C+CR	OVA+CR
Collagen Fibers (%)	7.73±1.27	18.90±1.31	5.26±0.69	11.98±0.75 †
Elastic Fibers (%)	6.50±0.55	16.43±1.04	5.73±0.68	7.81±0.76
MMP-9 (cells/10^4m^2)	1.30±0.89	18.30±2.59	0.00±0.00	4.82±0.61
TIMP-1 (cells/10^4m^2)	0.41±0.41	17.21±1.77	0.69±0.45	4.00±1.14 †
TGF- (cells/10^4m^2)	0.54±0.54	24.34±1.62	0.43±0.43	15.29±1.06 †
Mechanism	C	OVA	C+CR	OVA+CR
NF-B (cells/10^4m^2)	1.13±0.71	16.62±2.42	1.19±0.54	4.59±0.64