Profiling of Stem/Progenitor Cell Regulatory Genes of the Synovial Joint by Genome-Wide RNA-Seq Analysis

Figure 4

Immunohistochemistry of chondrogenesis related genes. (a-b) Sox9 was strongly expressed in both articular zone and mature zone. (c-d) Ihh was modestly positive in the articular zone, but intensely expressed in the mature zone. (e-h) Frzb and Dkk1 were detected in mature zone at a relative low level. (i, j) Lgr5 expression was primarily in the articular zone, but modest in the mature zone. (k, l) Tgfβ3 showed a similar expression pattern to Lgr5. Scale bar = 100 μm (a, c, e, g, i, k). Scale bar=25 μm (b, d, f, h, j, l).