Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice

Figure 4

Topical epidermal growth factor (EGF) reduced the infiltration of inflammatory cells in 2,4-dinitrochlorobenzene- (DNCB-) induced AD-like skin lesions. (a) The number of inflammatory cells increased in the positive control at 3 h and 24 h. There was reduced infiltration of inflammatory cells in both the EGF and pimecrolimus groups at 3 h and 24 h. (b) CD3 expression increased significantly in the positive group at 3 h and 24 h, and topical pimecrolimus or EGF reduced the level of CD3 expression. The data are represented in graphical form and show the fold changes compared with the normal control. < 0.05, < 0.01.

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(b)