Correlation between Soluble α-Klotho and Renal Function in Patients with Chronic Kidney Disease: A Review and Meta-Analysis

Table 1

Inclusion and exclusion criteria.

Inclusion criteria	(1) Investigation of the relationship between soluble α-klotho (measured in plasma or serum) and renal function associated indexes (eGFR was determined based on CKD-EPI or MDRD) in chronic kidney disease using correlation analyses.
	(2) Enrolling adults (mean age ≥18 years old).
	(3) Containing complete data information.
	(4) Research article published in the peer-reviewed journals.
Exclusion criteria	(1) Examination of the correlation between renal Klotho (mRNA or protein expression) and other related parameters.
	(2) Studies that didn’t contain correlation coefficients (R value) between renal function associated indexes in CKD and soluble α-klotho protein.
	(3) Special populations such as those who suffered from renal replacement therapy or study populations with one specific kidney disease, etc. Diabetic nephrology patients were excluded.
	(4) Animal-based experiments, in-vitro experiments, having no insufficient data, having significant overlap in the study populations, all duplicated publications, or enrolling only children
	(5) Case reports, posters, reviews and meeting abstracts