Intraoperative clinical images of the steps in segmental osteotomy and repair. Extraoral surgical approach to expose the mandible and depth grooving to mark the exact defect size (a). Fixation of mandibular segments with titanium reconstruction plate (b). Segmental mandibulectomy (15 mm) was performed and a titanium plate was used to rigidly fixate the two segments together. The resected mandibular segmental defect was implanted with anorganic bovine bone mineral collagen, functionalized with anti-BMP-2 mAb or isotype-matched control mAb (c).