Antibody-Mediated Osseous Regeneration for Bone Tissue Engineering in Canine Segmental Defects
Quantitative analysis of calcified tissues in the defect sites by CT scan imaging. (a) Comparison of bone density (Hounsfield Unit) of isotype mAb, rhBMP-2, and anti-BMP-2 mAb at 6th and 12th weeks. (b) Comparison of mineralized area (mm2) of isotype mAb, rhBMP-2, and anti-BMP-2 mAb at 6th and 12th weeks. Means and standard deviations were calculated in each group and statistical significance was assessed by general linear models for repeated measures and Tukey’s test as the post hoc test (; all other comparisons in each time point were not significant).