Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development

Table 3

Associations of the combined effect of RETN gene polymorphisms and betel nut chewing with the susceptibility to oral cancer among 1,465 smokers.

Variable	Controls (n=636) ()	Patients (n=829) ()	OR (95 CI)	AOR (95 CI)
rs3745367
GG genotype & non-betel nut chewing	178 (28.0%)	39 (4.7%)	1.00; (reference)	1.000; (reference)
GA or AA genotype or betel nut chewing	135 (21.2%)	291 (35.1%)	9.838 (6.580-14.708)	8.544 (5.668-12.880)
GA or AA genotype with betel nut chewing	323 (50.8%)	499 (60.2%)	7.051 (4.852-10.246)	5.838 (3.985-8.552)
rs7408174
TT genotype & non-betel nut chewing	218 (34.3%)	62 (7.5%)	1.00; (reference)	1.000; (reference)
TC or CC genotype or betel nut chewing	127 (20.0%)	385 (46.4%)	10.659 (7.540-15.068)	8.583 (6.026-12.225)
TC or CC genotype with betel nut chewing	291 (45.7%)	382 (46.1%)	4.616 (3.349-6.361)	4.105 (2.960-5.692)
rs1862513
GG genotype & non-betel nut chewing	166 (26.1%)	41 (5.0%)	1.00; (reference)	1.000; (reference)
GC or CC genotype or betel nut chewing	138 (21.7%)	289 (34.9%)	8.479 (5.698-12.617)	6.708 (4.467-10.074)
GC or CC genotype with betel nut chewing	332 (52.2%)	499 (60.1%)	6.085 (4.208-8.800)	5.090 (3.493-7.418)
rs3219175
GG genotype & non-betel nut chewing	287 (45.1%)	78 (9.4%)	1.00; (reference)	1.000; (reference)
GA or AA genotype or betel nut chewing	125 (19.7%)	448 (54.0%)	13.187 (9.583-18.147)	10.882 (7.861-15.064)
GA or AA genotype with betel nut chewing	224 (35.2%)	303 (36.6%)	4.977 (3.672-6.746)	4.134 (3.028-5.644)

The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression models that controlled for alcohol consumption.